ResearchGate | Find and share researchAt 298.2–318.2 K and 101.1 kPa, the solubility of FBX in several mono solvents was measured using an experimental approach proposed by “Higuchi and Connors” . The extra FBX was mixed with the known amount of each mono solvent. The obtained suspensions were vortexed for 10 min.Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google Scholar The CDs complexation of CIM was studied using the phase solubility diagrams method according to Higuchi and Connors. 20 Approximately 60 mg of microcrystalline CIM (A form) was added to 4 mL Britton-Robinson buffer (pH 9.8) ... Phase solubility techniques. Adv Anal Chem Instrum, 4 (1965), pp. 117-212. View in Scopus …A Way to Increase the Bioaccesibility and Photostability of Roflumilast, a COPD Treatment, by Cyclodextrin Monomers. In vitro digestion showed that CDs protect the drug during digestion and even improve its bioaccessibility, and points to the need to protect roflumilast from light, suggesting that tablets containing the drug might be reformulated.Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...The phase solubility analysis described by Higuchi and Connors is the most widely used method to describe inclusion complexation (Brewster and Loftsson 2007; Challa et al. 2005). The excess insoluble drug is placed in vials with a constant volume of aqueous carrier containing several solutions with high concentrations of CD.Phase solubility of FA/HP-β-CD complex. Phase solubility studies were carried out according the method described by Higuchi and Connors’s methods (1965). Excess amounts of FA were added to 10 ml of water solution of HP-β-CDs at different concentrations ranging from 0 to 8.5 mM.Mar 10, 2023 · Phase-solubility profiles and classification of drug/CD complexes according to Higuchi and Connors . Figure 2. In general, one drug molecule (D) forms a complex with one CD molecule in pure water, and, if the complex is water-soluble, an A L -type phase-solubility diagram is observed ( Table 1 ). Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added.ResearchGate | Find and share researchPhase solubility analysis was performed according to the method reported by Higuchi and Conners . An excess amount of RIF was added into a glass vial containing 1 mL of PBS solution (pH = 7.4) with various concentrations of ACB (0, 20, 40, 60, 80, 100 mM, respectively). ... Higuchi, T., Connors, K.A.: Phase-solubility techniques. Adv. …Derived from the slope of the linear phase solubility diagram, the apparent stability constant ... (25–100 mM), as described by Higuchi and Connors (1965). After shaking for 48 h at 37 °C ± 1 °C in a shaking water bath to reach equilibrium, samples were collected in triplicate and subsequently filtered through a 0.45 μm polyvinylidene ...The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug solubility ...T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following …According to the Higuchi and Connors classification [6], the phase solubility diagram for the repaglinide – HP- β-CD inclusion complex is A type, which indicates the formation of a soluble complex.ResearchGate | Find and share researchSolubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965). Assuming that the stoichiometry of the inclusion complex is 1:1, the solubility constant is given by the following equation: (1) K 1: 1 = s l o p e [T ...Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP--CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP--CD ing different concentrations of HP--CD, ranging from 14.3 mM ...May 1, 2022 · All experiments were repeated three times. According to the linear part of the phase solubility curve, the stability constant (Kc) was calculated using the Higuchi-Connors equation. (1) K c = S l o p e S 0 × (1-S l o p e) S 0: the solubility of NAR without β-CD. The solubilizing efficiency of β-CD was evaluated by the complexation efficiency ... Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; ChemistrySolubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965). Assuming that the stoichiometry of the inclusion complex is 1:1, the solubility constant is given by the following equation: (1) K 1: 1 = s l o p e [T ...The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...The elimina- tion half-life was estimated graphically from the terminal linear phase of the plasma concentra- tion-time curve. Results and Discussion The phase solubility diagram shown in Fig. 1 can be classified as type Bs according to Higuchi and Connors (1965). An insoluble microcrystalline complex was formed in solution at high CD ...In a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the guest...Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors ().The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. …The solubility of hydrocortisone (HC) was measured in water containing varying concentrations of γCD. The resulting B S-type phase-solubility diagram was described within the theoretical framework laid out by Higuchi and Connors. The initial linear increase in the solubility at low concentrations of γCD was caused by the …T. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, …Abstract The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability.In a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the guest...The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending.The phase solubility diagram (Fig. 2) showed that the solubility of cholesterol increased linearly with increasing β-CD concentration from 0 to 18 mmol/L (R 2 > 0.99). The phase solubility diagram was defined as the A L -type phase based on the early research of Higuchi and Connors (1965) , revealing the formation of inclusion complex …To improve the dissolution rate of poorly water soluble drugs, several techniques were used such as particle size reduction (formation of micro- and nano-systems), formation of water soluble complexes [14] and amorphous solid dispersion preparations [15]. ... According to Higuchi an Connors phase-solubility diagram …Solubility studies used deionized water, and 1 H NMR spectra were of solutions in deuterium oxide (D 2 O, deuterium content 99.8%) from Fluka (Barcelona, Spain). 2.2. Phase solubility studiesSolubility measurements were carried out according to the method of Higuchi and Connors (1965). Excess amounts of clofibrate were added to a series of ...Phase solubility test Phase solubility studies were performed according to the methods described by Higuchi and Connors ( Higuchi & Connors, 1965 ). Excess amounts of quinestrol was suspended in a 0.1 mol/L phosphate buffer solution (pH 7.0) containing increasing amounts of DM-β-CD (from 0 mM to 10.00 mM).Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has …The phase purity of the cocrystal samples prepared by rapid solvent evaporation and simple evaporation techniques was examined by PXRD based on the presence or absence of the characteristic peaks of the corresponding individual components ... Higuchi T, Connors KA. Phase-solubility techniques. Advan Anal Chem Instr. …Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117–212. [Google Scholar] 26. Doile KM ...18. Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117–212. 19. Higuchi T, Kristiansen H. Binding specificity between small organic solutes in aqueous Solution, Classification of some solutes into two groups according to binding tendencies. J Pharm Sei 1970;59:1601–8.Phase solubility study. Phase solubility studies were carried out according to the method reported by Higuchi and Connors . Excess amounts of MMF were added to 0.1 N HCl solutions (pH-1.2) containing para sulphonatocalix[4]resorcinarene in different molar concentrations and these flasks were then sonicated for 1 h and shaken at a rate …2.2. Phase solubility study. Analysis of phase solubility was implemented based on the method from Higuchi and Connors (Citation 1965). CAT (excess amount) was mixed with 20 mL of β-CD aqueous solutions in different concentration levels …phase solubility technique in studying the formation of complex salts of triamterene j pharm sci. 1964 nov;53:1325-8. doi: 10.1002/jps.2600531108.Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.Higuchi, KA Connors. Phase-solubility techniques. Adv Anal Chem Instrum 1965; 4: 117–212. Etodolak’ın Ko-kristalizasyonu: Ko-kristalizasyon Tahmini, Ko-kristal Sentezi, Katı Faz Yapı Aydınlatma Çalışmaları ve In Vitro İlaç Salımı ... Higuchi, KA Connors. Phase-solubility techniques. Adv Anal Chem Instrum 1965; 4: 117–212. Show All References …method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .Phase solubility studies were performed by the method previously reported by Higuchi and Connors . Briefly, excess amounts of darifenacin were added to 20 mL of aqueous solutions containing various concentrations of Hp βCD ... T. Higuchi and K. Connors, “Phase solubility techniques,” Advances in Analytical Chemistry and …Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ...In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation.Phase-solubility measurements. Phase-solubility measurements were carried out according to the method of Higuchi and Connors.14 Excess amount of 5-NI. ( ...The Higuchi and Connors 30 method was used to classify the phase-solubility profiles. The apparent stability constant ( K 1:1, eq 1 ) and the CE ( eq 2 ) were determined from the slope of the linear phase-solubility diagrams plots of the total drug solubility ([ D t ]) versus total concentration of CD in liquid phase ([CD liq ]) in moles per ...11 Tem 2017 ... Higuchi T, Connors KA. Phase solubility techniques. Advances in Analytical Chemistry and Instrumen- tation. New York, pp. 117–212 ...Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on a rotary shaker ...Phase-solubility studies were performed in triplicate by the method of Higuchi and Connors. ... Phase solubility techniques. Adv Anal Chem Instru 1965;4:17-123 ...Abstract. Levemopamil was solubilized by varying the concentration of hydroxypropyl- β -cyclodextrin (HP β CD) and by the alteration of pH. The drug molecule has two sites for possible complexation with HP β CD, creating the possibility of either 1:1 or 1:2 complexation. The solubility as a function of HP β CD concentration of the charged ...Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0–4% (w/v) were added in volumetric flasks in a PBS …Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.Jun 15, 2019 · Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ... Phase-solubility studies. Solubility measurements were performed in triplicate using the method reported by Higuchi and Connors [13]. An excess amount of CAR was added to the aqueous solutions of Soluplus® in water containing increasing concentrations of Soluplus® (0–20% w/v).Nowadays the application of cyclodextrin-assisted molecular encapsulation in foods offers many advantages. Cyclodextrins, their derivatives and their cross-linked polymers can all improve the quality of food in storage, remove specific components and stabilize and increase the presence components that are important for a healthy diet.Jan 1, 2011 · In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation. [16] T. Higuchi, K. A. Connors, “Phase Solubility Techniques”, Advances in Analytical Chemistry and Instrumentation, 4, 117-150, 1965. [17] T. Higuchi, H. Kristiansen, “Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies”, Journal …The plotted diagram displays a straight line with slopes less than 1, suggesting characteristic of Higuchi A L type. This indicate the formation of a 1:1 molecular ratio between the API and the CD. Using the Higuchi–Connors equation, the apparent solubility constant (K C) was determined from Fig. 1, resulting in a value of 122.01 M-1.T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ...Levemopamil was solubilized by varying the concentration of hydroxypropyl-β-cyclodextrin (HPβCD) and by the alteration of pH.The drug molecule has two sites for possible complexation with HPβCD, creating the possibility of either 1:1 or 1:2 complexation.The solubility as a function of HPβCD concentration of the charged and …Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro …The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ...phase solubility technique in studying the formation of complex salts of triamterene j pharm sci. 1964 nov;53:1325-8. doi: 10.1002/jps.2600531108.There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.The CDs complexation of CIM was studied using the phase solubility diagrams method according to Higuchi and Connors. 20 Approximately 60 mg of microcrystalline CIM (A form) was added to 4 mL Britton-Robinson buffer (pH 9.8) ... Phase solubility techniques. Adv Anal Chem Instrum, 4 (1965), pp. 117-212. View in Scopus …Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ...Phase solubility behavior was studied according to the method proposed by Higuchi and Connors ... Phase solubility techniques. Adv. Anal Chem Instrum 1965; 4: 117 ...Phase solubility curve of Sbio. Previously, the Higuchi-Connors phase-solubility method was used for assessing the compound stability constant (Higuchi & Connors, 1965). Briefly, extra Sbio was mixed with deionized water (Master-S, Hitech-sciencetool, Shanghai, PR China) containing 0–10 mM γ-CD. Then the suspensions …Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965). Assuming that the stoichiometry of the inclusion complex is 1:1, the solubility constant is given by the following equation: (1) K 1: 1 = s l o p e [T ...According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ...The phase solubility analysis described by Higuchi and Connors is the most widely used method to describe inclusion complexation (Brewster and Loftsson 2007; Challa et al. 2005). The excess insoluble drug is placed in vials with a constant volume of aqueous carrier containing several solutions with high concentrations of CD.7 May 2015 ... ... solubility method (Higuchi and Connors 1965). Figure 1 shows the phase ... Higuchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal ...Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentation 4: (1965) 127-212 4. F. Djedaïni, B. Perly, Nuclear Magnetic Resonance of cyclodextrin derivatives and inclusion compounds D. Duchene, New Trends in Cyclodextrins and Derivatives (1992) Editions de Santé Paris Ch. 6 5.Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0–4% (w/v) were added in volumetric flasks in a PBS …Phase Solubility Studies. The determination of the phase solubility diagram is a widely accepted method for evaluation of the effect of cyclodextrin complexation on the drug solubility. The phase solubility studies were performed by the method reported by Higuchi and Connors . Increasing concentrations of MβCD (0–0.23 M) or …The influence of HPB-CD on the solubility of BSC II compounds using phase solubility method (Higuchi ... Phase-solubility profiles of carbamazepine, danazol and ...To improve the dissolution rate of poorly water soluble drugs, several techniques were used such as particle size reduction (formation of micro- and nano-systems), formation of water soluble complexes [14] and amorphous solid dispersion preparations [15]. ... According to Higuchi an Connors phase-solubility diagram …K. A. Connors and J. J. Lipari. Effect of cycloamyloses on apparent dissociation constants of carboxylic acids and phenols: Equilibrium analytical selectivity induced by complex formation. J.to be considered in designing and carrying out these solubility studies. Experimental , The phase solubility technique permits the evaluation of the affinity between HPβCD and raloxife, The two kinds of CDs enhance the aqueous solubility of Res. As shown in Fig. 2, the phase-solubility diagrams o, Phase solubility studies. Excess FLB (50 mg) was mixed with 5 mL of distilled water , If inclusion complexation were the only contribution t, The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely u, The results showed an increase in the apparent solubility of ibuprofen in the , The phase solubility study was performed according to the method o, The phase solubility results indicated the formation of a IDE/SBE-β-CD, The mole fraction solubility of TDL was found to be highe, Phase solubility analysis The solubility measurements were pe, The two kinds of CDs enhance the aqueous solubility of Res. As shown i, Phase solubility. Compatibility of host and guest relationship , PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATI, Fig. 2 sums up the results of the phase-solubility studies performed , The solubility of hydrocortisone (HC) was measured, The most common and widely used method to evaluate the ability of th, The shake-fl ask method proposed by Higuchi and Co.